Effect of Primidone on Liver Enzymes Levels and Hepatic Tissue Changes in Adult Male Rats

Background: Primidone is effective in the treatment of epilepsy. In this research, effect of primidone on levels of liver enzymes and liver tissue change in adult male rats was studied. Material and Methods: For this purpose, 40 adult male wistar rats, weighing approximately 180-200 g were divided into 5 groups of 8 animals. Groups: control group, Sham group and treatment at doses of 20, 40, 60 mg/kg, orally for 42 days (every other day) respectively. At the end of the experiment , body weight were measured in all groups and then the blood sample was taken from heart and serum levels of AST, ALT, ALP and GGT enzymes were measured. Furthermore, The pathological changes of the livers were studied after hematoxylin-eosin staining. The results were analyzed using ANOVA and T-test statistical analysis. Results: the results show that body weight in experimental groups had not a significant difference compared to control group. Serum level in AST, ALT, ALP, GGT in experimental groups had a significant increase compared to control group (p≤0/05). In tissue samples in experimental groups which were provided a higher level of necrosis was observed. Conclusion: Primidone causes increase serum levels of AST, ALT, ALP, GGT and liver necrosis.